Major Depression
Articles in this topic explain how Major Depression can affect mood, focus, sleep, relationships, medication decisions, and day-to-day care conversations.
Men’s Mental Health: Why Asking for Help Feels Impossible
You already know something's off, and you've probably known for a while... months, maybe years.
Jul 1, 2025
Low T vs. Depression: What You Actually Need to Know
Guys come in convinced they have low T when they're actually depressed, and other guys come in convinced they're depressed when their testosterone is in…
Jun 25, 2025
Long-term med use realities (20-year horizons)
The honest answer to "can I stay on this medication for the rest of my life" is: we don't fully know what happens at 30 or 40 years out, because…
Jun 22, 2025
Antidepressant withdrawal vs relapse: distinguishing
Guys stop their antidepressant, feel terrible a couple weeks later, assume the depression is back, restart the medication. Sometimes that's right.
Jun 20, 2025
Depression, Explained
Depression ≠ sadness. Sadness has a thing it's about. Depression doesn't, it just follows you around like a Dementor sucking the light out of the world.
Jun 19, 2025
Zoloft
Zoloft is the drug I prescribe more than anything else, and the one patients ask the most questions about before they're willing to swallow the first pill.
Jun 13, 2025
Trintellix (Vortioxetine)
Trintellix is the antidepressant pharma reps spent a decade trying to make happen.
Jun 9, 2025
Why Men Avoid Therapy
Men kill themselves at roughly four times the rate women do in the US, that gap has held year after year, the pandemic didn't close it, the recession…
Jun 7, 2025
Pristiq (Desvenlafaxine)
Pristiq is what happens when you take Effexor, skip a metabolic step, and sell it as a new drug. That's not a dig, that's the actual mechanism.
May 27, 2025
The Difference Between Depression and Just Being Sad
Not every bad day is depression and not every hard week means you need medication.
May 21, 2025
Persistent Depressive Disorder (Dysthymia)
Persistent depressive disorder, what used to be called dysthymia, is the diagnosis for guys who've been depressed for so long they don't remember what…
May 9, 2025
Mood Disorders Treatment
"Mood disorder" is a category, not a diagnosis.
May 7, 2025