Major Depression
Articles in this topic explain how Major Depression can affect mood, focus, sleep, relationships, medication decisions, and day-to-day care conversations.
Depression, Explained
Depression ≠ sadness. Sadness has a thing it's about. Depression doesn't, it just follows you around like a Dementor sucking the light out of the world.
Jun 19, 2025
Zoloft
Zoloft is the drug I prescribe more than anything else, and the one patients ask the most questions about before they're willing to swallow the first pill.
Jun 13, 2025
Trintellix (Vortioxetine)
Trintellix is the antidepressant pharma reps spent a decade trying to make happen.
Jun 9, 2025
Why Men Avoid Therapy
Men kill themselves at roughly four times the rate women do in the US, that gap has held year after year, the pandemic didn't close it, the recession…
Jun 7, 2025
Pristiq (Desvenlafaxine)
Pristiq is what happens when you take Effexor, skip a metabolic step, and sell it as a new drug. That's not a dig, that's the actual mechanism.
May 27, 2025
The Difference Between Depression and Just Being Sad
Not every bad day is depression and not every hard week means you need medication.
May 21, 2025
Persistent Depressive Disorder (Dysthymia)
Persistent depressive disorder, what used to be called dysthymia, is the diagnosis for guys who've been depressed for so long they don't remember what…
May 9, 2025
Mood Disorders Treatment
"Mood disorder" is a category, not a diagnosis.
May 7, 2025
Why “Rock Bottom” Is Bullshit
Rock bottom is bullshit.
May 6, 2025
Sleep apnea + depression in middle-aged men
If you’re a guy in your forties or fifties who feels depressed, exhausted, foggy, and irritable, and the SSRI (selective serotonin reuptake inhibitor, the most common antidepressant class,…
Apr 28, 2025
Lurasidone (Latuda)
Lurasidone is the drug you reach for when somebody walks in with bipolar depression and a body that's already been wrecked by Seroquel.
Apr 16, 2025
Paxil (paroxetine)
Paxil is the SSRI (selective serotonin reuptake inhibitor, the standard first-line antidepressant class) I almost never start a new patient on, and the…
Apr 5, 2025