Abilify (aripiprazole)
Abilify is the drug I add to an antidepressant when the antidepressant is doing maybe sixty percent of the job and we need to find the other forty.…
Jun 1, 2026
Auvelity (dextromethorphan/bupropion)
Auvelity is a once-daily pill that combines dextromethorphan, the cough syrup ingredient, with bupropion, which most people know as Wellbutrin. It got FDA approval in 2022 for major…
Jun 1, 2026
Buprenorphine for depression and chronic pain
Buprenorphine is best known as an addiction medication, particularly for opioid use disorder, but a growing body of research and a quieter clinical practice have been using it…
Jun 1, 2026
Caplyta off-label use
Caplyta (lumateperone) is one of the newer atypical antipsychotics, FDA-approved for schizophrenia and bipolar depression, and what’s more interesting than its approved uses is what it’s quietly getting…
Jun 1, 2026
Compounded ketamine lozenges
For about five years, compounded ketamine troches and lozenges (small dissolving tablets made by specialty compounding pharmacies, taken at home) were the fastest-growing segment of mental health treatment…
Jun 1, 2026
ECT (Electroconvulsive Therapy)
ECT (electroconvulsive therapy, the one with the bad PR from the Jack Nicholson movie) works better than any antidepressant we have, and almost nobody who needs it gets…
Jun 1, 2026
Ketamine clinics: legit vs grift
The ketamine clinic boom of the last five years is two different things wearing one storefront. One is a real treatment with real data for the kind of…
Jun 1, 2026
Microdosing: what controlled trials actually show
The honest answer on microdosing is that the controlled trials don’t show much, the open-label data shows a lot, and the difference between those two things is mostly…
Jun 1, 2026
Ozempic, GLP-1s, and mood
The GLP-1 agonists (Ozempic and Wegovy and Mounjaro and the rest, a class of medications originally developed for type 2 diabetes and now used aggressively for weight loss)…
Jun 1, 2026
Pharmacogenomic testing for psych meds
GeneSight and the other pharmacogenomic tests (cheek-swab panels that look at your liver-enzyme genetics to suggest which psych medications you’ll handle well or badly) promise that a single…
Jun 1, 2026