Major Depression
Articles in this topic explain how Major Depression can affect mood, focus, sleep, relationships, medication decisions, and day-to-day care conversations.
ECT (Electroconvulsive Therapy)
ECT (electroconvulsive therapy, the one with the bad PR from the Jack Nicholson movie) works better than any antidepressant we have, and almost nobody who…
Jun 25, 2026
Three Months In on an SSRI: What to Expect
If you're reading this, you're probably somewhere between week eight and week twelve on an SSRI, you're trying to figure out whether it's working, and you…
Jun 19, 2026
The SSRI Waiting Game
The hardest part of starting an SSRI is the lag. Side effects can show up fast, while the benefit takes weeks.
May 16, 2026
Compounded ketamine lozenges
For about five years, compounded ketamine troches and lozenges (small dissolving tablets made by specialty compounding pharmacies, taken at home) were the…
Apr 20, 2026
Ozempic, GLP-1s, and mood
The GLP-1 agonists (Ozempic and Wegovy and Mounjaro and the rest, a class of medications originally developed for type 2 diabetes and now used…
Apr 16, 2026
Buprenorphine for depression and chronic pain
Buprenorphine is best known as an addiction medication, particularly for opioid use disorder, but a growing body of research and a quieter clinical…
Apr 14, 2026
Pharmacogenomic testing for psych meds
GeneSight and the other pharmacogenomic tests (cheek-swab panels that look at your liver-enzyme genetics to suggest which psych medications you'll handle…
Apr 12, 2026
Caplyta off-label use
Caplyta (lumateperone) is one of the newer atypical antipsychotics, FDA-approved for schizophrenia and bipolar depression, and what's more interesting…
Apr 10, 2026
Vraylar for depression augmentation
Vraylar (cariprazine) is an atypical antipsychotic that got an FDA add-on indication for major depression a few years back.
Apr 8, 2026
Auvelity (dextromethorphan/bupropion)
Auvelity is a once-daily pill that combines dextromethorphan, the cough syrup ingredient, with bupropion, which most people know as Wellbutrin.
Apr 6, 2026
Spravato (esketamine) protocol
Spravato is FDA-approved esketamine, given as a nasal spray under direct supervision in a certified clinic.
Apr 4, 2026
Microdosing: what controlled trials actually show
The honest answer on microdosing is that the controlled trials don't show much, the open-label data shows a lot, and the difference between those two…
Mar 22, 2026