Major Depression
Articles in this topic explain how Major Depression can affect mood, focus, sleep, relationships, medication decisions, and day-to-day care conversations.
Celexa (citalopram)
Celexa is the SSRI (selective serotonin reuptake inhibitor, the standard first-line antidepressant class that boosts serotonin without much else going on)…
Apr 2, 2025
Effexor (venlafaxine)
Effexor is the SNRI (serotonin-norepinephrine reuptake inhibitor, the antidepressant class that hits both serotonin and norepinephrine instead of just…
Mar 31, 2025
Trazodone
Trazodone is the most prescribed sleep medication in the United States that was never actually approved as a sleep medication.
Mar 25, 2025
Cognitive Behavioral Therapy (CBT)
CBT (cognitive behavioral therapy, the structured worksheet-and-homework kind, not the talk-about-your-mother kind) is the therapy with the most evidence…
Feb 4, 2025
Cymbalta (Duloxetine)
Cymbalta is the drug I reach for when the depression has a physical component...
Feb 1, 2025
Lexapro (Escitalopram)
Lexapro is the SSRI I start with most of the time, and the reason is boring...
Jan 29, 2025
When to switch antidepressants, and when to stay
Half the antidepressant switches that happen shouldn't have happened, and the other half should have happened six months earlier.
Jan 27, 2025
Choosing between SSRIs, SNRIs, and what comes next
The decision tree for picking an antidepressant in 2026 isn't really a tree, it's more like a workflow, and the workflow is a lot simpler than the size of…
Jan 24, 2025
How long does an antidepressant actually take to work?
Eight to twelve weeks at a real dose.
Jan 16, 2025
Does Wellbutrin actually not cause sexual side effects?
The short version: mostly true, the marketing is shading it slightly cleaner than it actually is, and the most useful clinical move with Wellbutrin in…
Jan 14, 2025
What the men’s mental health movement gets wrong
There are basically two wings of the men's mental health conversation in 2026 and both of them are selling stuff, which is most of the problem.
Jan 11, 2025