Pristiq (Desvenlafaxine)
Pristiq is what happens when you take Effexor, skip a metabolic step, and sell it as a new drug. That’s not a dig, that’s the actual mechanism. Venlafaxine…
May 27, 2025
The Difference Between Depression and Just Being Sad
Not every bad day is depression and not every hard week means you need medication. Sometimes life is just difficult, you feel like shit about it, and that’s…
May 21, 2025
Mood Disorders Treatment
“Mood disorder” is a category, not a diagnosis. Under that umbrella sit a half dozen actually-different illnesses: regular old depression, bipolar I, bipolar II, cyclothymia, premenstrual dysphoric disorder,…
May 7, 2025
Why “Rock Bottom” Is Bullshit
Rock bottom is bullshit. The idea that addicts and depressed people have to lose the marriage, lose the job, lose the house, get the DUI, wake up in…
May 6, 2025
Ketamine
Ketamine has been around since 1962, doing its boring day job as an anesthetic in operating rooms and battlefield medic kits, and the depression piece is the much…
May 1, 2025
High Dose Ketamine – In Clinic
High-dose ketamine done in a clinic is a different animal from the troches you take at home. Same molecule, different dose, different route, and a completely different experience.…
Apr 22, 2025
Lurasidone (Latuda)
Lurasidone is the drug you reach for when somebody walks in with bipolar depression and a body that’s already been wrecked by Seroquel. It’s an atypical antipsychotic (the…
Apr 16, 2025
Trazodone
Trazodone is the most prescribed sleep medication in the United States that was never actually approved as a sleep medication. Built as an antidepressant in the 1960s, came…
Mar 25, 2025
Low Dose Ketamine – At Home
At-home ketamine is the version of this treatment most people end up actually doing. Less because it’s better than the IV in a clinic, more because it costs…
Mar 2, 2025