Major Depression
Articles in this topic explain how Major Depression can affect mood, focus, sleep, relationships, medication decisions, and day-to-day care conversations.
Why “Rock Bottom” Is Bullshit
Rock bottom is bullshit.
May 6, 2025
Ketamine
Ketamine has been around since 1962, doing its boring day job as an anesthetic in operating rooms and battlefield medic kits, and the depression piece is…
May 1, 2025
Sleep apnea + depression in middle-aged men
If you’re a guy in your forties or fifties who feels depressed, exhausted, foggy, and irritable, and the SSRI (selective serotonin reuptake inhibitor, the most common antidepressant class,…
Apr 28, 2025
High Dose Ketamine In Clinic
High-dose ketamine done in a clinic is a different animal from the troches you take at home.
Apr 22, 2025
Lurasidone (Latuda)
Lurasidone is the drug you reach for when somebody walks in with bipolar depression and a body that's already been wrecked by Seroquel.
Apr 16, 2025
Paxil (paroxetine)
Paxil is the SSRI (selective serotonin reuptake inhibitor, the standard first-line antidepressant class) I almost never start a new patient on, and the…
Apr 5, 2025
Celexa (citalopram)
Celexa is the SSRI (selective serotonin reuptake inhibitor, the standard first-line antidepressant class that boosts serotonin without much else going on)…
Apr 2, 2025
Effexor (venlafaxine)
Effexor is the SNRI (serotonin-norepinephrine reuptake inhibitor, the antidepressant class that hits both serotonin and norepinephrine instead of just…
Mar 31, 2025
Trazodone
Trazodone is the most prescribed sleep medication in the United States that was never actually approved as a sleep medication.
Mar 25, 2025
Low Dose Ketamine At Home
At-home ketamine is the version of this treatment most people end up actually doing.
Mar 2, 2025
Cognitive Behavioral Therapy (CBT)
CBT (cognitive behavioral therapy, the structured worksheet-and-homework kind, not the talk-about-your-mother kind) is the therapy with the most evidence…
Feb 4, 2025
Cymbalta (Duloxetine)
Cymbalta is the drug I reach for when the depression has a physical component...
Feb 1, 2025