Condition

Major Depression

Articles in this topic explain how Major Depression can affect mood, focus, sleep, relationships, medication decisions, and day-to-day care conversations.

Lexapro (Escitalopram)
Medications · 10 min read

Lexapro (Escitalopram)

Lexapro is the SSRI I start with most of the time, and the reason is boring...

Jan 29, 2025
When to switch antidepressants, and when to stay
Comparison · 10 min read

When to switch antidepressants, and when to stay

Half the antidepressant switches that happen shouldn't have happened, and the other half should have happened six months earlier.

Jan 27, 2025
Choosing between SSRIs, SNRIs, and what comes next
Comparison · 11 min read

Choosing between SSRIs, SNRIs, and what comes next

The decision tree for picking an antidepressant in 2026 isn't really a tree, it's more like a workflow, and the workflow is a lot simpler than the size of…

Jan 24, 2025
How long does an antidepressant actually take to work?
Q&A · 10 min read

How long does an antidepressant actually take to work?

Eight to twelve weeks at a real dose.

Jan 16, 2025
Does Wellbutrin actually not cause sexual side effects?
Q&A · 11 min read

Does Wellbutrin actually not cause sexual side effects?

The short version: mostly true, the marketing is shading it slightly cleaner than it actually is, and the most useful clinical move with Wellbutrin in…

Jan 14, 2025
What the men’s mental health movement gets wrong
Off Script · 9 min read

What the men’s mental health movement gets wrong

There are basically two wings of the men's mental health conversation in 2026 and both of them are selling stuff, which is most of the problem.

Jan 11, 2025