Lamictal (lamotrigine)
Lamictal is one of those medications I actually like prescribing, which is not a sentence I get to write very often in psychiatry. The people on it tend…
Jun 1, 2026
Lithium
Lithium is the best mood stabilizer we have for bipolar I, and we don’t use it nearly enough. That’s the whole post, more or less. The rest is…
Jun 1, 2026
MAT (Medication-Assisted Treatment) full landscape
If you have opioid use disorder, medication is the actual treatment. Not therapy first, not 12-step first, not the white-knuckle abstinence approach that’s been the default for forty…
Jun 1, 2026
Microdosing: what controlled trials actually show
The honest answer on microdosing is that the controlled trials don’t show much, the open-label data shows a lot, and the difference between those two things is mostly…
Jun 1, 2026
Naltrexone for alcohol
Naltrexone is the medication that gets prescribed more than any other for alcohol use disorder in clinics that actually know what they’re doing, and it’s the one most…
Jun 1, 2026
Ozempic, GLP-1s, and mood
The GLP-1 agonists (Ozempic and Wegovy and Mounjaro and the rest, a class of medications originally developed for type 2 diabetes and now used aggressively for weight loss)…
Jun 1, 2026
Pharmacogenomic testing for psych meds
GeneSight and the other pharmacogenomic tests (cheek-swab panels that look at your liver-enzyme genetics to suggest which psych medications you’ll handle well or badly) promise that a single…
Jun 1, 2026
Pregabalin (Lyrica)
Pregabalin is gabapentin’s better-looking, more expensive cousin. Same mechanism family, more aggressive marketing, much higher price, and a controlled substance in the US for reasons that have to…
Jun 1, 2026
Seroquel (quetiapine)
Seroquel is the antipsychotic that gets prescribed for everything other than what it’s actually approved for, and the off-label sleep use is the biggest example. There are real…
Jun 1, 2026
Spravato (esketamine) protocol
Spravato is FDA-approved esketamine, given as a nasal spray under direct supervision in a certified clinic. It’s the only legal-and-insured version of ketamine for treatment-resistant depression (TRD, which…
Jun 1, 2026