Tricyclic Antidepressants

Tricyclics are older antidepressants that can still help depression, pain, migraine, and sleep, but overdose risk and anticholinergic side effects keep them out of the casual lane.

Tricyclics are older antidepressants that can still help depression, pain, migraine, and sleep, but overdose risk and anticholinergic side effects keep them out of the casual lane.

Knowing better doesn’t mean shit if you’re not doing better. We all know that guy. Reads all the right books, quotes all the right people, posts about the work constantly… and he’s still hungover half the week, still dodging the…

The hardest part of starting an SSRI is the lag. Side effects can show up fast, while the benefit takes weeks.

Semen retention gets a bad rap and a pile of mystical hype. The honest version: dropping compulsive porn helps, the superpowers don't.

It's normal and it's not tanking your testosterone. The only real question is whether it's a habit or a compulsion.

Sleep medications can be useful short-term tools, but insomnia is rarely solved by pretending sedation is the same thing as healthy sleep.

Confidence isn't a feeling you wait for. It's evidence you build by turning intention into specific action.
Tadalafil is the one erectile dysfunction medication that doesn’t care what time you took it. You can take it Friday morning and it’ll still be working Saturday night. That’s not marketing copy, that’s just the pharmacology. The window of effect…

Here’s something everybody agrees on before we get anywhere near the science, which is that nobody’s ever hoped things would get a little drier, in any situation, ever, and your body’s right there with you on that. It wants wet,…

Typical antipsychotics are older dopamine-blocking drugs that can still be useful, especially in acute psychosis and agitation, but movement side effects are the central trade.

Going soft at 24 feels like the end of the world. It's usually your head, not your plumbing, and it's far more common and more fixable than anyone lets on.

Atypical antipsychotics can be exactly right for psychosis, bipolar disorder, and depression augmentation. They aren't casual sleep pills.