Factsheet
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Buprenorphine for depression and chronic pain
Buprenorphine is best known as an addiction medication, particularly for opioid use disorder, but a growing body of research and a quieter clinical…
Apr 14, 2026
Caplyta off-label use
Caplyta (lumateperone) is one of the newer atypical antipsychotics, FDA-approved for schizophrenia and bipolar depression, and what's more interesting…
Apr 10, 2026
Vraylar for depression augmentation
Vraylar (cariprazine) is an atypical antipsychotic that got an FDA add-on indication for major depression a few years back.
Apr 8, 2026
Auvelity (dextromethorphan/bupropion)
Auvelity is a once-daily pill that combines dextromethorphan, the cough syrup ingredient, with bupropion, which most people know as Wellbutrin.
Apr 6, 2026
Spravato (esketamine) protocol
Spravato is FDA-approved esketamine, given as a nasal spray under direct supervision in a certified clinic.
Apr 4, 2026
Doxepin for sleep
Doxepin is a tricyclic antidepressant from the 1960s that turned out, at very low doses, to be one of the best sleep medications available.
Apr 2, 2026
Pregabalin (Lyrica)
Pregabalin is gabapentin's better-looking, more expensive cousin.
Mar 31, 2026
Vivitrol (extended-release naltrexone)
Vivitrol is naltrexone in a syringe, given once a month in your butt. That's the whole pitch.
Mar 28, 2026
Naltrexone for alcohol
Naltrexone is the medication that gets prescribed more than any other for alcohol use disorder in clinics that actually know what they're doing, and it's…
Mar 26, 2026
Seroquel (quetiapine)
Seroquel is the antipsychotic that gets prescribed for everything other than what it's actually approved for, and the off-label sleep use is the biggest…
Mar 24, 2026
Suboxone (buprenorphine/naloxone)
Suboxone is the closest thing we have to a miracle drug in psychiatry, and most of the people who need it spent years being talked out of taking it by…
Mar 12, 2026
Abilify (aripiprazole)
Abilify is the drug I add to an antidepressant when the antidepressant is doing maybe sixty percent of the job and we need to find the other forty.
Mar 10, 2026