Abilify (aripiprazole)
Abilify is the drug I add to an antidepressant when the antidepressant is doing maybe sixty percent of the job and we need to find the other forty.…
Jun 1, 2026
Auvelity (dextromethorphan/bupropion)
Auvelity is a once-daily pill that combines dextromethorphan, the cough syrup ingredient, with bupropion, which most people know as Wellbutrin. It got FDA approval in 2022 for major…
Jun 1, 2026
Buprenorphine for depression and chronic pain
Buprenorphine is best known as an addiction medication, particularly for opioid use disorder, but a growing body of research and a quieter clinical practice have been using it…
Jun 1, 2026
Caplyta off-label use
Caplyta (lumateperone) is one of the newer atypical antipsychotics, FDA-approved for schizophrenia and bipolar depression, and what’s more interesting than its approved uses is what it’s quietly getting…
Jun 1, 2026
Doxepin for sleep
Doxepin is a tricyclic antidepressant from the 1960s that turned out, at very low doses, to be one of the best sleep medications available. The 3mg and 6mg…
Jun 1, 2026
Klonopin (Clonazepam)
The pitch for Klonopin, the one I hear from prescribers and from the guys who’ve been on it for years, is that it’s the cleaner benzo. Longer half-life,…
Jun 1, 2026
Lamictal (lamotrigine)
Lamictal is one of those medications I actually like prescribing, which is not a sentence I get to write very often in psychiatry. The people on it tend…
Jun 1, 2026
Lithium
Lithium is the best mood stabilizer we have for bipolar I, and we don’t use it nearly enough. That’s the whole post, more or less. The rest is…
Jun 1, 2026
Naltrexone for alcohol
Naltrexone is the medication that gets prescribed more than any other for alcohol use disorder in clinics that actually know what they’re doing, and it’s the one most…
Jun 1, 2026
Pregabalin (Lyrica)
Pregabalin is gabapentin’s better-looking, more expensive cousin. Same mechanism family, more aggressive marketing, much higher price, and a controlled substance in the US for reasons that have to…
Jun 1, 2026