Caplyta off-label use
Caplyta (lumateperone) is one of the newer atypical antipsychotics, FDA-approved for schizophrenia and bipolar depression, and what’s more interesting than its approved uses is what it’s quietly getting…
Jun 1, 2026
Lamictal (lamotrigine)
Lamictal is one of those medications I actually like prescribing, which is not a sentence I get to write very often in psychiatry. The people on it tend…
Jun 1, 2026
Lithium
Lithium is the best mood stabilizer we have for bipolar I, and we don’t use it nearly enough. That’s the whole post, more or less. The rest is…
Jun 1, 2026
Seroquel (quetiapine)
Seroquel is the antipsychotic that gets prescribed for everything other than what it’s actually approved for, and the off-label sleep use is the biggest example. There are real…
Jun 1, 2026
Bipolar Treatment
Bipolar treatment goes wrong in the first appointment more often than in any later one. Get the diagnosis wrong and every prescription after it is wrong. And bipolar…
Aug 27, 2025
Mood Disorders Treatment
“Mood disorder” is a category, not a diagnosis. Under that umbrella sit a half dozen actually-different illnesses: regular old depression, bipolar I, bipolar II, cyclothymia, premenstrual dysphoric disorder,…
May 7, 2025
Caplyta (Lumateperone)
Caplyta is the antipsychotic that came out in 2019 and made a bunch of psychiatrists do a double-take at the receptor pharmacology, then another double-take at the price…
Apr 23, 2025
Lurasidone (Latuda)
Lurasidone is the drug you reach for when somebody walks in with bipolar depression and a body that’s already been wrecked by Seroquel. It’s an atypical antipsychotic (the…
Apr 16, 2025